We source our platelets exclusively from FDA-regulated donation banks in the United States. After the approved transfusion window has passed, select, qualified, healthy donors are carefully chosen for our process. These platelets are gently processed to isolate their delicate exosomes, which are then rigorously tested to ensure exceptional purity and safety.

Our serums are formulated in the United States using FDA-approved platelet sources. ( plated ) Skin Science serums are formulated in our Rochester, Minnesota laboratories, where these ethically sourced, human platelet-derived exosomes are incorporated into our proprietary Renewosome® technology, developed by physician-scientists from Mayo Clinic. This controlled process ensures high levels of purity, potency, and consistency from batch to batch.

( plated ) Skin Science serums are absorbed into the skin through surface cells of the epidermis and through hair follicles. The molecular structure of every platelet-derived exosome is under 150 nanometers in diameter (over 500 times smaller than a pore on our skin). This allows for easy access and penetration through the skin or scalp.

Think of platelet-derived exosomes as tiny egg-like packages filled with powerful, naturally occurring phosphoproteins, peptides, and antioxidant enzymes that renew and regenerate the look of skin and hair. Exosomes work at their fullest potential when these packages keep their shell, and that's what makes ( plated ) serums stand out.

Our proprietary Renewosome® technology processes platelet-derived exosomes using an advanced, extremely gentle ultrafiltration process that preserves their "shell" (aka lipid bilayer) intact. With the shell intact, platelet-derived exosomes are remarkably stable. They can be stored at room temperature for up to a year without degrading.

By comparison, other brands that require refrigeration typically extract exosomes using a very disruptive process called centrifugation. This places enormous pressure on delicate exosomes, causing their "shell" to crack. This means the serums must be refrigerated and used quickly after formulation to have any chance of having an impact on skin.

We recommend storing your serums at room temperature. Please avoid storing any of your products at temperatures below 50°F (10°C) or above 95°F (35°C) for extended periods.

Our platelet-derived exosome serums are shelf-stable for up to 12 months when stored correctly. Please keep them out of extreme heat or cold to maximize longevity.

( plated ) Skin Science serums are designed to be used once or twice daily as the first step after cleansing. Apply a small amount to clean, dry skin and allow the serum to fully absorb for at least 5 minutes before applying additional products (or, in the case of HAIR Serum, heat styling). For best results, follow the instructions provided with each serum and use consistently to support visible renewal.

While results can vary by skin type and reason for use, most participants in clinical studies reported a positive impact after 6 weeks. Platelet-derived exosomes provide continuous renewal, which means the longer you use them, the better the results. Studies show that results build over time. Six weeks means a visible difference, while six months is a true transformation.

( plated ) is a cosmetic topical product line.

( plated ) Skin Science platelet-derived exosome serums contain only gentle ingredients and are not formulated with harsh actives that are known to be unsafe during pregnancy or breastfeeding.

However, if you are pregnant or breastfeeding, it's important to always consult with your doctor before using new skincare products, including ( plated ) Skin Science serums. A detailed ingredient list is available on our product pages.

( plated ) Skin Science does not currently operate retail store locations. Our products are available through leading dermatologists, plastic surgeons, healthcare professionals, and aesthetic practices, as well as directly through our website.

We also offer a dedicated partnership program for qualified skincare providers. If you're interested in carrying ( plated ) in your practice, please visit our provider page.

To get in touch, please email info@platedskinscience.com or fill out the form on our Contact Us page. We love to hear from you and are always ready to answer your questions!

Both the INTENSE Serum and DAILY Serum are breakthrough formulas that deliver next-level anti-aging results through the power of platelet-derived exosomes.

• INTENSE Serum (15 ml) is our most concentrated exosome formula. It's best suited for stressed or aging skin and was designed to address the most challenging skin concerns, including the look of mature skin, stubborn pigmentation, fine lines, and dullness. It's clinically proven to deliver 2x younger-looking skin, reduce the appearance of wrinkles, dark spots, and uneven tone, while boosting luminosity and glow.
• DAILY Serum (30 ml) features a lower exosome concentration and a higher concentration of hydrating ingredients. It's known as the "glow" serum for a reason. DAILY Serum infuses the skin with visible renewal to improve radiance. It's best suited for daily anti-aging protection, sensitive or barrier-compromised skin, and anyone looking for a luminous glow. It's clinically proven to reveal brighter skin, smooth the look of fine lines, fight the look of redness and dark spots, and defend against future signs of aging.

For the ultimate results, many skincare pros recommend combining DAILY Serum and INTENSE Serum for a complete, 24-hour rejuvenation ritual.

• Morning: Apply DAILY Serum to lock in hydration, boost radiance, and protect your barrier throughout the day.
• Night: Apply INTENSE Serum to maximize your skin's natural renewal cycle while you sleep, targeting signs of aging more deeply.

For a dramatic transformation and youthful appearance, INTENSE Serum and DAILY Serum pair wonderfully with EYE Serum. The delicate and ultra-thin skin around our eyes ages differently (and often faster) than the rest of the skin on our face. That's why it requires a special formula designed to serve this specific skin and the concerns that come with it, including the appearance of undereye bags, dark circles, crepey skin, hooded eyelids, and more.

These serums also pair well with HAIR Serum to deliver younger-looking, fuller, thicker hair alongside BODY Serum, which is formulated to unlock visibly smoother, firmer, more radiant-looking skin everywhere below the chin, including the chest, arms, hands, legs, knees, and elbows.

You may also wish to pair ( plated ) Skin Science serums with other products like retinol or vitamin C. For optimal results, it's recommended to apply the ( plated ) product first. Once applied, please allow it to set for 5 minutes before adding any additional products.

Retinoids and vitamin C are skincare heavy hitters, but pairing them with the wrong products can sometimes lead to dryness, irritation, or stalled results. The good news? ( plated ) Skin Science serums are designed to work with these powerful actives, not against them. Learn more about layering ( plated ).

The carrier gel used within INTENSE Serum and DAILY Serum contains hyaluronic acid. This molecule, which is naturally found in the body, works to increase skin moisture and reduce the appearance of fine lines and wrinkles.

INTENSE Serum is our most concentrated anti-aging exosome serum, powered by proprietary Renewosome® technology. It's a medical-grade formula designed for the most challenging skin concerns: fine lines, wrinkles, redness, brown spots, and uneven tone and texture. Apply once daily.

INTENSE Serum helps improve the appearance of the most challenging signs of aging: fine lines, wrinkles, redness, brown spots, and uneven tone and texture.

Clinically, it's been shown to deliver 2x younger-looking skin, reduce the appearance of wrinkles and dark spots, and boost luminosity and glow. Most people see visible results within 6 weeks, with a transformation that builds over time.

INTENSE Serum is for anyone looking to target more advanced or stubborn signs of aging with our most concentrated formula. It's suitable for all skin types and is an especially strong fit when fine lines, wrinkles, brown spots, or uneven tone and texture are your top concerns. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

Apply INTENSE Serum 1 to 2 times per day on a dry face right after cleansing. Wait 5 minutes to allow the platelet-derived exosomes to get to work before layering any other products. With millions of exosomes per pump, one pump per application is all you need.

Depending on your individual skin goals and your aesthetic provider's guidance, INTENSE Serum and DAILY Serum can be used as part of the same anti-aging regimen. Start your morning with DAILY Serum, drenching skin in hydration while supporting your barrier and bringing out a healthy, lit-from-within glow. At night, switch to INTENSE Serum, working in sync with your skin's natural renewal cycle to visibly smooth, refine, and restore while you sleep.

Yes! In fact, according to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol.

For best results, always apply ( plated ) serums first to clean, product-free skin. And, let it sit for 5 minutes before applying other products. The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once you've waited, feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.

No. Our INTENSE Serum will not cause sun sensitivity. You can apply it in the morning or at night as you wish. In fact, the platelet-derived exosomes that power Renewosome® technology have been shown to help deliver advanced environmental protection against oxidative damage from UVA/UVB rays, pollution, and more. Of course, we still recommend you use your favorite daily SPF.

You may choose to stick to CALM Serum or transition to INTENSE Serum (maximum exosome concentration for mature or stressed skin) or DAILY Serum (renewing support for a youthful glow). Your provider can help you select the best choice for your skin goals.

( plated ) Skin Science is the #1 dermatologist-recommended exosome brand for a reason: the science is backed by 10+ gold-standard clinical studies that show one thing: platelet-derived exosomes lead to visible transformation. As our most advanced exosome serum, INTENSE Serum delivers the most cutting-edge exosome science and technology to your skincare routine.

Developed by Mayo Clinic physician-scientists over 20+ years, ( plated ) serums represent a true breakthrough for aging skin. They harness the power of platelet-derived exosomes and their remarkable cargo to visibly renew the skin while remaining soothing and gentle. So many serums are only as good as the next cleanse.

Don't forget, a little serum (just one pump) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use. An investment, for sure. Clinical studies show a compounding effect; the longer you use INTENSE Serum, the more your results build. Think of it like a long-term investment for your skin, where every application adds up over time.

An investment for sure, but worth it? Definitely! You'll see these results for years to come.

DAILY Serum is our deeply hydrating, platelet-derived exosome serum, known as the "glow" serum, powered by proprietary Renewosome® technology. This medical-grade formula infuses the skin with visible renewal for everyday radiance, applied once daily.

DAILY Serum deeply hydrates and infuses the skin with visible renewal to improve radiance. Clinically, it's been shown to reveal brighter skin, smooth the look of fine lines, and reduce the appearance of redness and dark spots, while helping defend against future signs of aging.

DAILY Serum for anyone looking for daily anti-aging protection and a luminous glow. Its gentle, hydrating formula makes it an especially good fit for sensitive or barrier-compromised skin. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

DAILY Serum can be used either in the morning or at night as the first step in your skincare routine.

DAILY Serum is formulated for everyday use. Apply to clean, dry skin 1–2 times daily. Wait 5 minutes before layering any other skincare product.

Yes! For best results, always apply ( plated ) exosome serums first to clean, product-free skin. And, let it sit for 5 minutes before applying other products.

The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. After waiting 5 minutes, feel free to layer on any other products, such as retinol, retinoids, vitamin C, moisturizer, or sunscreen. Don't forget your SPF.

Yes. DAILY Serum is formulated to be gentle and hydrating, making it appropriate for all skin types, including sensitive skin.

You may choose to stick to CALM Serum or transition to DAILY Serum (renewing support for a youthful glow) or INTENSE Serum (maximum exosome concentration for mature or stressed skin). Your provider can help you select the best choice for your skin goals.

EYE Serum is our targeted platelet-derived exosome serum for the eye area, powered by proprietary Renewosome® technology and blended with hyaluronic acid and caffeine from coffee arabica extract. This medical-grade formula is designed to improve the appearance of the delicate skin above and below the eye: from puffiness and dark circles to fine lines.

EYE Serum targets both quick and long-term eye-area concerns. Its hyaluronic acid and caffeine can deliver nearly instant visible improvement in the appearance of under-eye puffiness, wrinkles, and dark circles, while its platelet-derived exosomes work on a deeper level over time.

In our consumer study, participants saw a reduction in the appearance of crow's feet, fine lines, crepey texture, and sagging skin in about 4 weeks. And, applied in a full circle around the eye, it's been shown to reduce the appearance of eyelid wrinkles and hooded eyes.

EYE Serum is for anyone looking to address the appearance of puffiness, dark circles, crow's feet, fine lines, crepey texture, or hooded eyes. It's formulated to be safe for all skin types, including sensitive skin. In our consumer study, there were zero reports of adverse effects.

Use one pump daily (half a pump per eye, above and below the lash line). One bottle is designed to last about two and a half months.

You may notice immediate improvement in the appearance of under-eye puffiness, wrinkles, and dark circles thanks to the hyaluronic acid and caffeine in the coffee arabica extract, which can provide nearly instant visible effects.

Our platelet-derived exosomes work to visibly renew the look of aging skin. In our consumer study, participants began to show these deeper results, including a reduction in the appearance of crow's feet, fine lines, crepey texture, and sagging skin, in about 4 weeks with EYE Serum.

If you use the recommended one pump per day (half a pump per eye area), the EYE Serum is designed to last approximately two and a half months. This may vary depending on how often and how much serum you apply.

Yes, definitely! In fact, you'll get the most benefit if you do. EYE Serum is safe and effective for the entire eye area, above and below, right up to the lash line. When applied in a full circle around the eye, it has been shown to reduce the appearance of eyelid wrinkles and hooded eyes.

Yes, the EYE Serum is formulated to be safe for all skin types, including sensitive skin. In our consumer study, there were zero reports of adverse effects.

HAIR Serum is a groundbreaking scientific achievement in hair and scalp science. Developed by Mayo Clinic physician-scientists and based on 20+ years of research, HAIR Serum is a breakthrough for at-home hair renewal.

HAIR Serum uses powerful platelet-derived exosome technology, fortified with antioxidants, phosphoproteins, and a proprietary blend of nurturing ingredients, to help improve the appearance of hair density, thickness, volume, and strength.

HAIR Serum is ideal for individuals experiencing hair-related concerns such as thinning hair, shedding, or lack of volume or density, as it helps improve the appearance of these issues. It's appropriate and effective for all genders, ages, and hair types.

HAIR Serum harnesses the power of platelet-derived exosomes in a shelf-stable formula to regenerate the hair's look. Our exosomes come directly from platelets, the body's first responders for hair renewal. They serve as the primary vehicle for delivering the look of healthy, thick hair.

The hero ingredient of HAIR Serum is platelet-derived exosomes, which deliver potent renewal technology to support the scalp and visibly improve hair density, volume, and thickness, while improving the appearance of scalp coverage. HAIR Serum is fortified by other science-backed ingredients, including biotin, sea moss, hyaluronic acid, and turmeric.

Yes. In a double-blind, placebo-controlled clinical study of HAIR Serum, participants experienced remarkable results:

• 100% of participants showed improvement in scalp coverage appearance
• 96% reported improved appearance of volume and fullness
• 3x improvement in the appearance of hair density
• Visual improvement across 10 key hair health indicators
• No side effects or downtime
  

Studies show that the platelet-derived exosomes in HAIR Serum can aid in helping the body set the stage for strong, healthy-looking hair. Our proprietary formula has been shown to improve the appearance of scalp coverage while increasing the look of volume, fullness, density, and thickness.

The platelet-derived exosomes in HAIR Serum get to work immediately on the scalp, but when it comes to hair, patience is key. Here's what you can expect:

• 1–3 months: Exosome technology goes to work, reprogramming the look of the scalp and hair.
• 4–6 months: The appearance of scalp coverage improves, and patchiness decreases.
• 6+ months: Enjoy the look of your new fuller, thicker, healthier hair.

With regular use, the HAIR Serum helps maintain its benefits, making hair appear fuller, stronger, and thicker.

Yes, continued use of the HAIR Serum is recommended to maintain your hair's appearance. Regular application can help sustain the benefits and improvements over the long term.

Because platelet-derived exosomes support continuous renewal at the scalp, the longer you use HAIR Serum, the greater the benefits. In clinical studies, participants continued to see improvements in the appearance of thickness, volume, fullness, strength, and scalp coverage with continued use.

Apply 1–2 pre-loaded droppers of HAIR Serum directly onto the scalp in areas of concern. Gently massage into the scalp to distribute evenly. Wait 5 minutes before applying other products or heat styling.

You can apply the product to either wet, damp, or dry hair, making it versatile for your needs.

For the best results, gently massage HAIR Serum into the scalp to distribute evenly. It's recommended to wait 5 minutes before applying other products or heat styling to ensure optimal absorption and effectiveness.

HAIR Serum is formulated by combining platelet-derived exosomes with an innovative blend of science-backed ingredients designed to boost the appearance of the hair's density, thickness, volume, and overall appearance. Check out the detailed ingredient list here:

• Platelet-derived exosomes are nanosized vesicles that unlock the scalp's innate ability to renew for thicker, fuller hair.
• Our innovative antioxidant blend helps reduce the appearance of hair and scalp damage due to emotional stress, sun exposure, and environmental pollutants.
• Biotin inspires stronger-looking hair.
• Hyaluronic acid conditions and hydrates your scalp.
• Turmeric provides skin-calming properties.
• Lindera strychnifolia root extract primes the skin on your scalp.

HAIR Serum is designed for cosmetic use only. If you are receiving microneedling or PRP through a healthcare provider, we recommend you speak with them about post-procedure care instructions.

Yes, HAIR Serum is formulated to benefit all hair types. In fact, in clinical studies, 100% of patients of different ages and genders reported an improvement in the appearance of scalp coverage.

Each bottle of HAIR Serum contains 90 droppers, enough for a 3-month supply at one drop per day.

The dropper pre-loads as you unscrew the cap. The dropper should appear about half full; there's no need to pull up more. When it comes to platelet-derived exosomes, a little goes a long way. There are millions of exosomes in every dropper, enough to spread across several targeted areas. Remember to apply it directly to the scalp and gently massage it in, rather than applying it to the hair.

Using more serum than recommended or applying it more frequently does not guarantee better results. Additionally, this may cause the bottle to be depleted more quickly than expected.

HAIR Serum is not specifically formulated for eyebrows or beards, but we continually explore new potential uses and benefits of platelet-derived exosome technology.

HAIR Serum is formulated to support fuller, healthier-looking hair by improving the appearance of density, strand thickness, shine, moisture, and overall hair vitality. While the formula is designed to enhance the overall look and health of your hair, it was not developed to address hair discoloration or reverse grey hair.

HAIR Serum is the first and only at-home cosmetic treatment to use the breakthrough power of platelet-derived exosomes. HAIR Serum is different in a few important ways:

• Inclusive skincare for everyone: In clinical studies, HAIR Serum improved the appearance of scalp coverage for 100 percent of people across all ages, genders, and hair types.
• Zero side effects: Participants in our clinical studies reported no adverse events. That's a stark contrast to other treatments that can have serious side effects for men and women.
• Continuous exosome renewal: Platelet-derived exosomes work continuously to renew the hair and improve the appearance of density for fuller, thicker-looking strands.
• The invisible-dry formula leaves no detectable residue, so you can style and go without heavy oils or foams weighing down your hair.
  

BODY Serum is the world's first platelet-derived exosome serum designed specifically for total-body renewal and anti-aging below the chin. In a 75mL bottle designed to cover more skin with every application, it's clinically proven to visibly improve the appearance of tone, texture, hydration, and elasticity.

BODY Serum helps visibly renew skin on the chest, hands, arms, and legs for a firmer, smoother, more youthful appearance. It addresses the most common visible signs of body skin aging, including crepey-looking skin, the appearance of redness, uneven tone, and dryness.

Apply BODY Serum once daily to clean, dry skin, focusing on the areas you most want to treat, such as the chest, upper arms, and knees. Allow it to fully absorb (about 5 minutes) before layering other products.

Yes. Depending on your individual skin goals and your aesthetic provider's guidance, the recommended approach is to target each area of the body with the formulation tailored to it. ( plated ) Skin Science has you covered from head to toe: EYE Serum for the periorbital area around the eyes, INTENSE Serum or DAILY Serum for the face and neck, HAIR Serum for the scalp, and BODY Serum for the body.

No. BODY Serum is specifically designed for the unique needs of body skin. Compared to the face, skin on the body is thicker, contains fewer oil glands, and renews more slowly. INTENSE Serum and DAILY Serum are optimized for the greater sensitivity of facial skin, with a higher concentration of platelet-derived exosomes to maximize visible results on the face.

No. BODY Serum will not cause sun sensitivity, so you can apply it in the morning or evening, whenever it fits your routine. Platelet-derived exosome technology also offers antioxidant support that helps defend the look of skin against everyday environmental stressors like sun and pollution. Of course, we still recommend you use your daily SPF!

CALM Serum is our provider-exclusive, post-procedure exosome serum, powered by proprietary Renewosome® technology. Unlike our other serums, it's formulated with added ingredients to hydrate, soothe, and improve skin tolerability after ablative and non-ablative aesthetic procedures.

CALM Serum is applied 2-3 times a day after an ablative or non-ablative procedure to help soothe the skin, support recovery, and enhance procedure results. In the CALM study, patients showed significant improvement within 5 days post-procedure. Most patients then transition to INTENSE Serum or DAILY Serum to maintain results and add hydration, luminosity, and glow.

CALM Serum is for patients preparing for or recovering from cosmetic procedures and is used under the guidance of a healthcare or aesthetic professional. It's carried exclusively by providers and isn't sold directly to consumers, so your provider can advise how best to use it for your treatment. If your provider doesn't yet offer CALM Serum, you can email info@platedskinscience.com or fill out the form on our Contact Us page.

CALM Serum can be applied 2-3 times a day after an ablative or non-ablative procedure to help decrease recovery time and enhance the results of the procedure.

Your healthcare provider or aesthetic professional will advise you on how best to use CALM Serum following a laser treatment.

Most patients transition to exosome-powered INTENSE Serum or DAILY Serum after CALM Serum to help maintain results and enhance hydration, luminosity, and glow.

CALM Serum is designed as a post-procedure product with added ingredients to enhance hydration, soothe the skin, and improve tolerability post-procedure.

Patients using CALM Serum demonstrated significant improvement within 5 days of being post-procedure.

In the CALM study, an Ultra Pulse CO₂ laser was used in the study at the following settings: Energy: 125 mJ, Density: 3, 10 HZ, Size: 5-7, Pattern: 1

CALM Serum is carried exclusively by healthcare professionals and aesthetic providers so they can help you prepare your skin for cosmetic treatments and reduce post-procedure recovery time. If your local aesthetics provider does not yet offer CALM Serum, please email info@platedskinscience.com or fill out the form on our Contact Us page.

It takes us 2-3 business days to process your order. Once processing is complete, we will ship your order. Delivery, depending on location, will typically arrive within 5-7 business days. A notification email will be sent to you on the day your product ships with your tracking details. For additional details, please view our shipping policy.

Yes, we're happy to offer free standard shipping for all orders within the U.S.!

At this time, ( plated ) Skin Science does not offer expedited shipping options. Orders are shipped via our standard delivery service. For additional details, please view our shipping policy.

At this time, orders placed on our website only ship within the United States. We look forward to expanding to international destinations in the future. For additional details, please view our shipping policy.