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( plated ) Skin Science INTENSE Serum Refill cartridge with 'Time' magazine's 'Best Inventions' award badge
Gold INTENSE Serum skincare bottle on a beige background with text about what this serum addresses.
Diagram of science-backed ingredients for skincare with text and examples.
Before-and-after comparison of the eye area of a 61-year-old female, which states significant improvement in the look of fine lines and wrinkles
Hand holding ( plated )'s INTENSE Serum bottle with application instructions on a beige background
Scientific rendering of an exosome on a beige background, featuring text about Renewosome™ technology.
INTENSE Serum 15 mL bottle, refill cartridge and packaging with text stating refills are only available for the latest version of the INTENSE bottle.
Video of the INTENSE Serum 15 mL bottle coming apart to reveal the refill cartridge on a white background.
( plated )® Skin Science INTENSE Refill Serum cartridge and packaging on a white background.
4.7
Rated 4.7 out of 5 stars
723

INTENSE Serum Refill

Our Most Advanced Exosome Serum

Sale price$244.00
15 mL Refill 15 mL Bottle

Visible transformation takes time. With each use, platelet-derived exosomes help support your skin’s natural renewal, driving results that continue to build long-term. Our refillable design keeps you consistent, with $14 savings built into every bottle.

Size: 15 mL / 0.5 fl oz

MUST have the full-size INTENSE Serum for the refill to work properly.
From TIME. © 2024 TIME USA LLC. All rights reserved.

Ingredients

Platelet-Derived Exosomes

Nanosized vesicles that unlock the skin’s innate ability to renew, visibly rewinding the look of damaged, aging skin.

Hyaluronic Acid

Low molecular weight hyaluronic acid supports renewing potential of exosomes, while increasing skin hydration.

Innovative Antioxidant Blend

Reduces free radical damage to help skin maintain a healthy, youthful appearance.

All Ingredients

water, glycerin, pentylene glycol, panthenol, human platelet extract, polyacrylate crosspolymer-6, hyaluronic acid, caprylyl glycol, 1,2-hexanediol, hydrolyzed gelatin, arginine, silanetriol

Instructions

Apply 1–2 times daily on clean, dry skin before any other skincare. Wait 5 minutes before layering additional products. Results amplify over time with consistent use.

Awards

TIME Best Inventions 2024

Oprah Daily Editor's Choice 2024

Oprah Daily Editor's Choice 2023

NewBeauty Award Winner 2025

NewBeauty Award Winner 2024

GQ Grooming Award 2025

Cosmopolitan Holy Grail Beauty Award 2025

Marie Claire Hair & Skin Award (Best Serum for Mature Skin) 2025
( plated ) Skin Science INTENSE Serum Refill cartridge with 'Time' magazine's 'Best Inventions' award badge
INTENSE Serum Refill Sale price$244.00
Hand holding a bottle of ( plated ) INTENSE Serum and an INTENSE Serum Refill cartridge.

Renew. Refill. Repeat.

How to Refill

Step 1: Twist the bottom of the reusable pump to remove the empty cartridge.

Step 2: Unscrew the cap of the new refill cartridge, insert into the pump, and twist to secure.

Step 3: Close your empty cartridge and recycle. Enjoy your exosomes!
Hand holding a gold ( plated ) INTENSE Serum bottle, applying product to another hand.

True Change Takes Time

Platelet-derived exosomes support your skin’s natural renewal process for results that build over time. In clinical studies, results continued to improve long-term, helping to:

  • Deliver 2x younger-looking skin
  • Reduce the appearance of fine lines and wrinkles
  • Fight the look of dark spots and uneven tone
  • Boost luminosity and promote a radiant glow

Exosome Science in Action

Visibly Transformative Results

Before and after comparison of a person's face with visible skin improvement over 11 weeks.
Before and after comparison of a woman's face with visible skin texture changes after using INTENSE Serum with 'Baseline' on the left and '12 Weeks' on the right.
Before and after comparison of a man's face with visible skin texture changes over 12 weeks.

Where Biotech Meets Beauty™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

EXPLORE THE SCIENCE
4.7
Rated 4.7 out of 5 stars
Based on 723 reviews
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723 reviews
  • Janis M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/27/26
    Best anti wrinkle serum ever

    Expensive but worth every dollar

    Was this helpful?
  • Cheryl F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/26/26
    5 Stars

    I look 10 yrs. younger than when I first started Plated 3 yrs. ago. When I look in the mirror what I see reflects how I feel, my best self without surgery!

    Was this helpful?
  • Holly C.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/24/26
    Amazing serum

    These are the best skincare products I've ever used.

    Was this helpful?
  • Brenda S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/23/26
    My skin looks better

    I started using this product a little less than a month ago. I use it at night only; one pump per side of my face. My skin is looking much better. Will keep using

    Was this helpful?
  • Maureen M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/23/26
    Life changing

    This product has been transformative. Cannot recommend highly enough!

    Was this helpful?
  • Samiha F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/23/26
    Number 1

    Best serum I ever used

    Was this helpful?
  • KATHLEEN M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/22/26
    Intense, Eye and Hair serums

    I feel like this has simplified my whole skincare regime.

    When my dermatologist told me I would need less moisturizer etc, I was skeptical, but she was right. My skin is healthier and more vibrant. Thank you!

    Was this helpful?
  • Pam G.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/22/26
    Very effective serum

    Been using awhile and it works great on dark spots. I’m 68 so not sure it’s going to get rid of my wrinkles, but seems to help.

    Was this helpful?
  • Marie S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/22/26
    Best facial creme I have tried

    Noticed a big difference in one week

    Was this helpful?
  • Mallory M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/22/26
    10/10 would (will!) purchase again

    My mother who is stingy with compliments said my face looks amazing and asked if it was Botox. (I do get Botox, but it was several weeks 'old'). It's absolutely the INTENSE Serum. I met a (plated) rep at skincare event and he gifted me samples of the regular daily serum and the intense serum. The daily was incredible and I purchased the intense figuring more is more. It is more than I hoped for - truly love this stuff. The eyewatering price is worth it.

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INTENSE Serum Refill

Frequently Asked Questions

What is ( plated ) INTENSE Serum?

INTENSE Serum is our most concentrated anti-aging exosome serum, powered by proprietary Renewosome® technology. It's a medical-grade formula designed for the most challenging skin concerns: fine lines, wrinkles, redness, brown spots, and uneven tone and texture. Apply once daily.

What does ( plated ) INTENSE Serum do?

INTENSE Serum helps improve the appearance of the most challenging signs of aging: fine lines, wrinkles, redness, brown spots, and uneven tone and texture.

Clinically, it's been shown to deliver 2x younger-looking skin, reduce the appearance of wrinkles and dark spots, and boost luminosity and glow. Most people see visible results within 6 weeks, with a transformation that builds over time.

Who is ( plated ) INTENSE Serum for?

INTENSE Serum is for anyone looking to target more advanced or stubborn signs of aging with our most concentrated formula. It's suitable for all skin types and is an especially strong fit when fine lines, wrinkles, brown spots, or uneven tone and texture are your top concerns. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

How often should I apply ( plated ) INTENSE Serum?

Apply INTENSE Serum 1 to 2 times per day on a dry face right after cleansing. Wait 5 minutes to allow the platelet-derived exosomes to get to work before layering any other products. With millions of exosomes per pump, one pump per application is all you need.

Do I use ( plated ) INTENSE and DAILY Serum at the same time?

Depending on your individual skin goals and your aesthetic provider's guidance, INTENSE Serum and DAILY Serum can be used as part of the same anti-aging regimen. Start your morning with DAILY Serum, drenching skin in hydration while supporting your barrier and bringing out a healthy, lit-from-within glow. At night, switch to INTENSE Serum, working in sync with your skin's natural renewal cycle to visibly smooth, refine, and restore while you sleep.

Can you use the ( plated ) INTENSE Serum with other products like retinol or vitamin C?

Yes! In fact, according to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol.

For best results, always apply ( plated ) serums first to clean, product-free skin. And let it sit for 5 minutes before applying other products. The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once you've waited, feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.

Does ( plated ) INTENSE Serum cause sun sensitivity?

No. Our INTENSE Serum will not cause sun sensitivity. You can apply it in the morning or at night as you wish. In fact, the platelet-derived exosomes that power Renewosome® technology have been shown to help deliver advanced environmental protection against oxidative damage from UVA/UVB rays, pollution, and more. Of course, we still recommend you use your favorite daily SPF.

After a skin procedure such as laser treatment, microneedling, or chemical peel, is it best to transition to ( plated ) INTENSE Serum after using ( plated ) CALM Serum?

You may choose to stick to CALM Serum or transition to INTENSE Serum (maximum exosome concentration for mature or stressed skin) or DAILY Serum (renewing support for a youthful glow). Your provider can help you select the best choice for your skin goals.

What makes ( plated ) INTENSE Serum worth the investment?

( plated ) Skin Science is the #1 dermatologist-recommended exosome brand for a reason: the science is backed by 10+ gold-standard clinical studies that show one thing: platelet-derived exosomes lead to visible transformation. As our most advanced exosome serum, INTENSE Serum delivers the most cutting-edge exosome science and technology to your skincare routine.

Developed by Mayo Clinic physician-scientists over 20+ years, ( plated ) serums represent a true breakthrough for aging skin. They harness the power of platelet-derived exosomes and their remarkable cargo to visibly renew the skin while remaining soothing and gentle. So many serums are only as good as the next cleanse.

Don't forget, a little serum (just one pump) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use. An investment, for sure. Clinical studies show a compounding effect; the longer you use INTENSE Serum, the more your results build. Think of it like a long-term investment for your skin, where every application adds up over time.

An investment for sure, but worth it? Definitely! You'll see these results for years to come.