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( plated ) Skin Science INTENSE Serum Refill cartridge with 'Time' magazine's 'Best Inventions' award badge
Gold INTENSE Serum skincare bottle on a beige background with text about what this serum addresses.
Diagram of science-backed ingredients for skincare with text and examples.
Before-and-after comparison of the eye area of a 61-year-old female, which states significant improvement in the look of fine lines and wrinkles
Hand holding ( plated )'s INTENSE Serum bottle with application instructions on a beige background
Scientific rendering of an exosome on a beige background, featuring text about Renewosome™ technology.
INTENSE Serum 15 mL bottle, refill cartridge and packaging with text stating refills are only available for the latest version of the INTENSE bottle.
Video of the INTENSE Serum 15 mL bottle coming apart to reveal the refill cartridge on a white background.
( plated )® Skin Science INTENSE Refill Serum cartridge and packaging on a white background.
4.7
Rated 4.7 out of 5 stars
619

INTENSE Serum Refill

Our Most Advanced Exosome Serum

Sale price$244.00
15 mL Refill 15 mL Bottle

Visible transformation takes time. With each use, platelet-derived exosomes help support your skin’s natural renewal, driving results that continue to build long-term. Our refillable design keeps you consistent, with $14 savings built into every bottle.

Size: 15 mL / 0.5 fl oz

MUST have the full-size INTENSE Serum for the refill to work properly.
From TIME. © 2024 TIME USA LLC. All rights reserved.

Ingredients

Platelet-Derived Exosomes

Nanosized vesicles that unlock the skin’s innate ability to renew, visibly rewinding the look of damaged, aging skin.

Hyaluronic Acid

Low molecular weight hyaluronic acid supports renewing potential of exosomes, while increasing skin hydration.

Innovative Antioxidant Blend

Reduces free radical damage to help skin maintain a healthy, youthful appearance.

All Ingredients

water, glycerin, pentylene glycol, panthenol, human platelet extract, polyacrylate crosspolymer-6, hyaluronic acid, caprylyl glycol, 1,2-hexanediol, hydrolyzed gelatin, arginine, silanetriol
Instructions

Apply 1–2 times daily on clean, dry skin before any other skincare. Wait 5 minutes before layering additional products. Results amplify over time with consistent use.
Awards

TIME Best Inventions 2024

Oprah Daily Editor's Choice 2024

Oprah Daily Editor's Choice 2023

NewBeauty Award Winner 2025

NewBeauty Award Winner 2024

GQ Grooming Award 2025

Cosmopolitan Holy Grail Beauty Award 2025

Marie Claire Hair & Skin Award (Best Serum for Mature Skin) 2025
( plated ) Skin Science INTENSE Serum Refill cartridge with 'Time' magazine's 'Best Inventions' award badge
INTENSE Serum Refill Sale price$244.00
Hand holding a bottle of ( plated ) INTENSE Serum and an INTENSE Serum Refill cartridge.

Renew. Refill. Repeat.

How to Refill

Step 1: Twist the bottom of the reusable pump to remove the empty cartridge.

Step 2: Unscrew the cap of the new refill cartridge, insert into the pump, and twist to secure.

Step 3: Close your empty cartridge and recycle. Enjoy your exosomes!
Hand holding a gold ( plated ) INTESE Serum bottle, applying product to another hand.

True Change Takes Time

Platelet-derived exosomes support your skin’s natural renewal process for results that build over time. In clinical studies, results continued to improve long-term, helping to:

  • Deliver 2x younger-looking skin
  • Reduce the appearance of fine lines and wrinkles
  • Fight the look of dark spots and uneven tone
  • Boost luminosity and promote a radiant glow

Exosome Science in Action

Visibly Transformative Results

Before and after comparison of a person's face with visible skin improvement over 11 weeks.
Before and after comparison of a woman's face with visible skin texture changes after using INTENSE Serum with 'Baseline' on the left and '12 Weeks' on the right.
Before and after comparison of a man's face with visible skin texture changes over 12 weeks.

Where Biotech Meets Beauty™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

EXPLORE THE SCIENCE
4.7
Rated 4.7 out of 5 stars
Based on 619 reviews
Total 5 star reviews: 503
Total 4 star reviews: 57
Total 3 star reviews: 33
Total 2 star reviews: 17
Total 1 star reviews: 9
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619 reviews
  • Tim L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    8/1/26
    Intense serum

    I noticed results right away. I highly recommend recommended. I’m in intensive care physician work under a lot of stress. The nurses know my skin looks better when I start taking care of my skin. Intense serum is fantastic ofantastic.

    Was this helpful?
  • Tiffany O.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/31/26
    This product is absolutely Amazing!

    This product is absolutely amazing! It has evened out my skin tone and blended my undertones beautifully. It has significantly reduced my hyperpigmentation—better than any other product I’ve ever used. My complexion looks smoother, brighter, and more balanced. I’m beyond impressed with the results!

    Was this helpful?
  • Renee D.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/31/26
    Love it

    Absolutely love the gold Plated serum. I’ve been using it for about 6 months now. My skin is brighter, fuller and just plain healthy I appearance. I use it day and night.

    Was this helpful?
  • Ginger S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/30/26
    Plated products.

    I love plated products I do a refill on the serum. Because I use it every day and night. I believe it’s the best product on the market. My son is an aesthetician and recommends it to all of his clients.

    Was this helpful?
  • Erika M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/30/26
    Helps with my retinoids

    I love this even if it is expensivez. I have sensitive skin but this allows me to use stronger treatments like my tretinoin and helps me recover faster from microneedling

    Was this helpful?
  • Linda L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/30/26
    After using the product, my skin feels smoother, and the issue of dryness has been alleviated.

    After using the product, my skin feels smoother, and the dryness has been alleviated.

    Was this helpful?
  • catherine f.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/29/26
    The best

    Honestly, it is the best serum I have ever used!

    Was this helpful?
  • CARA B.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/29/26
    Best serum

    I started using plated products after being introduced to them by my aesthetician. Yes they are expensive but a little goes a long way. My skin looks great and my hair is actually filling in along my hairline where it was thinning. Just ordered the new body serum and can’t wait to try it. Go ahead and see for yourself.

    Was this helpful?
  • Anny B.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/29/26
    Wow

    I have been using the serum for the past four weeks and have seen a significant improvement in my skin. Smile lines are diminishing ,scars are erasing ,and has improved overall texture of the skin. I wished the bottle was bigger and wished it wasn’t so expensive but I see why it has that price tag because it really does repair the skin in a short time. I definitely will re-purchase again and hopefully I can find some type of coupon lol

    Was this helpful?
  • Allison S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    7/29/26
    Liquid Gold

    I bought this during exosome days. Use every night and for me to purchase the refill says a lot. I’m so picky with skincare & I’ve noticed such a difference in my skin since using it. Thank you and please don’t ever stop making it! Excited to try body product once it’s launched.

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INTENSE Serum Refill

Frequently Asked Questions

What is the purpose of the ( plated ) INTENSE Serum?

In just weeks, the clinically proven INTENSE Serum targets the visible signs of aging with results you can see!

INTENSE Serum is our most concentrated anti-aging exosome serum, formulated specifically to improve the appearance of the most challenging skin needs, such as fine lines, wrinkles, redness, brown spots, tone, and texture.
How often should I apply the INTENSE Serum?

Apply INTENSE Serum 1 to 2 times per day on a dry face right after cleansing. Allow the product to dry completely (approximately 5 minutes) before layering other products.

With millions of exosomes per pump, one pump per application is all you need.
Do I use the INTENSE and DAILY Serum at the same time?

Depending on your individual skin goals and the guidance of your aesthetic provider, the recommended approach is to begin with the INTENSE Serum for 6-12 weeks to support visible renewal. After completing this initial phase, many people transition to the DAILY Serum to help maintain results and support ongoing skin maintenance.
Can you use the INTENSE Serum with other products like retinol or vitamin C?

Yes! According to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol!

For best results, always apply ( plated ) serums first to clean, product-free skin. And, let it sit for 5 minutes before applying other products.

The exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once the INTENSE Serum has dried, you'll know it has absorbed, and you can feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.
What makes ( plated ) INTENSE Serum worth the investment?

Backed by clinically proven results and recommended by top aestheticians, injectors, dermatologists, and plastic surgeons, ( plated ) delivers the most cutting-edge science and technology to your skincare routine.

The science behind ( plated ) serums was carefully researched and curated over more than 15 years to bring the power of platelet-derived exosomes, their remarkable cargo, and renewing power into a powerful serum while also being soothing and gentle.

Our serums truly have the impact and action of multiple products in one! ( plated ) offers the power of platelet-derived exosomes, antioxidants, peptides, amino acids, collagen, and hyaluronic acid (a powerhouse serum that replaces many steps).

Don't forget, a little serum (just one pump!) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use!

An investment, for sure. But, worth it!? Definitely! Because you're worth the investment!