Best Exosomes for the Face: How to Choose a Serum that Delivers Real Results

Best Exosomes for the Face Plated Platelet-Derived Exosomes Intense Serum and Daily Serum

QUICK TAKE: BEST EXOSOMES FOR THE FACE

  • Exosome skincare represents a major leap forward in anti-aging, helping renew the skin’s appearance at a deeper, more comprehensive level than traditional serums. 
  • Not all exosome products actually work. Sourcing and scientific backing matter. The best exosomes for facial skincare come from brands with peer-reviewed clinical data.
  • ( plated )® Skin Science is the #1 dermatologist recommended exosome skincare brand, powered by 20+ years of science and highly purified platelet-derived exosomes.
  • Platelet-derived exosomes are clinically proven to improve the look of fine lines, dark spots, redness, texture, and thinning or sagging skin.
  • Exosome serums like INTENSE Serum and DAILY Serum provide broad, adaptive renewal with fewer steps — replacing the need for multiple separate serums.

 

For thousands of years, humans have been enthralled by the promise of anti-aging skincare. Did you know that the word “cosmetics” actually came from the Greek “kosmetikos”? Ancient Greeks used to pile on wild olive oil and honey in the service of a younger-looking complexion, while Cleopatra famously bathed in donkey milk to soften and nourish her skin. 

Now that beauty has entered a more evidence-based era, however, science can and should inform our approach to what really works in beauty. Perhaps the most promising ingredient to be developed this decade is the one word that has the beauty world buzzing: exosomes. That’s because these tiny nanoparticles act like superfuel to naturally renew the skin and restore a healthier, more youthful look. Here’s exactly what exosomes for the face can do—and how to choose the best exosomes to deliver unmatched results.           

What Is Exosome Skincare?

Exosome skincare is a true game-changer when it comes to what’s possible for anti-aging and glowing skin. Clinically validated exosome serums can deliver remarkable benefits for the face. As our skin’s natural fuel for renewal, they seek out different kinds of issues with the skin’s appearance and seek to correct them. This means they have the power to adapt to your specific issues to address different sorts of problems from the look of fine lines and wrinkles to the appearance of dark spots and redness to the look of sagging or thinning skin. 

It’s important to remember that while there are many exosome serums on the market, very few are backed by scientific evidence and clinical data to prove that they actually deliver on their promises. ( plated )® Skin Science is the number-one dermatologist-recommended exosome skincare and a TIME’s Best Invention of the year for a reason. Backed by 20+ years of science, multiple peer-reviewed studies, and clinical research, serums for the face, including DAILY Serumand INTENSE Serum are proven to correct multiple visible signs of aging on the face. Think: reducing the look of fine lines and wrinkles, evening the appearance of dark spots and redness, and enhancing luminosity and glow—all in as little as six weeks.

 

What Makes Exosomes Different Than Traditional Skincare?

Exosome skincare represents a fundamental shift in how we think about results-driven skincare. Traditional serums make you chase concerns one by one — a product for the look of wrinkles, another for dark spots, another for hydration. All of a sudden, you have a 12-step routine that’s not just difficult to stay consistent with, but it can be counterproductive. All that layering can lead to irritation instead of improvement.

Exosomes work differently. Rather than targeting a single issue the way an acid might focus only on texture, properly sourced exosomes support broad, visible renewal. Platelet-derived exosomes work with the skin’s natural processes to help refresh its overall appearance, creating a more youthful-looking complexion. The result: one intelligent technology that can address multiple visible concerns at once — without the downsides of an overloaded routine.

 

Plated Skin Science INTENSE Serum Best Exosomes for Face

What Are the Best Exosomes for the Face?

The best exosomes for the face are products backed by scientific evidence and clinical research. Here’s why ( plated )® Skin Science serums, including INTENSE Serum and DAILY Serum are the best exosome serums currently on the market:

The #1 dermatologist recommended exosome skincare.

Medically trained skincare doctors understand exactly how the skin works and what it needs to look its very best. They are not likely to be persuaded by flashy marketing. Instead, they look at the scientific evidence behind every product they recommend. That’s why ( plated )® Skin Science stands out as the top choice among the most knowledgeable skincare experts. 

Backed by 20+ years of regenerative science.

The platelet-derived exosomes that power ( plated )® Skin Science serums were studied and developed into a shelf-stable formula thanks to more than two decades of regenerative science by top physician-scientists based in Rochester, Minn. Revolutionary science continues to be the brand’s north star with continued research to push skincare beyond where it's ever been before. 

Powered by platelet-derived exosomes.

The tiny nanoparticles known as exosomes can come from lots of different places. They are present in different areas of the body—and in other animals and plants, too. So how do you choose which exosomes are best for the face? Platelet-derived exosomes are uniquely beneficial for the appearance of the skin. Exosomes from platelets have one clear superpower: “Renew and Refresh!” They address areas of visible damage and help nourish with nutrients like phosphoproteins, peptides, and antioxidants to rejuvenate the skin’s appearance. 

Breakthrough results in an at-home formula.

Like any ingredient, exosomes are only effective in a daily serum if they remain shelf-stable. The breakthrough behind ( plated )® lies in a proven method for extracting platelet-derived exosomes in their complete, intact form. These whole exosomes retain their lipid bilayer, which protects their contents, preserves their potency, and prevents degradation over time. Think of the bilayer as a protective shell—keeping the exosomes stable and ensuring they can deliver their full benefits where skin needs them most.

Clinically proven to renew the look of the skin.

Backed by clinical research, platelet-derived exosomes are proven to improve the look of multiple signs of aging to deliver healthier-, younger-looking, and even more luminous skin. 

 

Are Exosomes Safe for the Face? 

In multiple clinical studies, ( plated )® Skin Science serums have been shown to be gentle for the face — even for very sensitive skin. Exosomes are nanosized particles naturally present in the skin. Unlike plant- or animal-derived ingredients, platelet-derived exosomes speak the same love language as your skin. That means it’s very unlikely that your skin will have a negative reaction. 

What’s more, ( plated )® Skin Science formulations are free of common irritants like fragrances, dyes, alcohols, oils, and waxes. The platelet-derived exosomes are delivered alongside only clinically validated, gentle ingredients to let them speak for themselves when it comes to renewal. In fact, INTENSE Serum contains only 12 ingredients compared to the 50+ ingredient list you often see in other anti-aging serums. Thanks to the purified nature of the formulas, they are generally safe for all skin types, including sensitive and blemish-prone skin. 

For topical skincare, platelet-derived exosomes undergo an advanced purification process long before they reach your bottle.

 

Exosome Results: Before and Afters

Understanding the science behind platelet-derived exosomes is great — but sometimes you want to see what all of this renewing power means when it comes to real changes in the skin’s appearance. Check out these before-and-afters for INTENSE Serum — our most concentrated and powerful exosome serum— to see the difference these amazing nanoparticles can make.


 

How to Choose an Exosome Serum

 When you’re choosing between scientifically proven exosome serums, it’s best to let your own skin needs and goals be your guide. INTENSE Serum, DAILY Serum, and EYE Serum are all powered by the incredible renewing power of platelet-derived exosomes. The difference is in the potency of the exosome concentration and the clinically proven ingredients that support the exosomes within the formulation. Here’s a quick guide:

( plated )® Skin Science INTENSE Serum

INTENSE Serum

Best for those targeting visible signs of aging. INTENSE Serum is designed to work harder to target aging concerns that demand immediate attention. With the most intense exosome concentration per application, INTENSE Serum regenerates the skin’s appearance faster and more dramatically.

( plated )® Skin Science DAILY Serum

DAILY Serum

Best for those who want the ultimate, skin-perfecting glow. DAILY infuses your skin with the visible renewal and protection it needs to stay resilient and radiant-looking over time. It’s ideal if you’re looking to nurture your skin, while addressing moderate signs of aging and stopping more severe signs before they start.

( plated )® Skin Science EYE Serum

EYE Serum

Best for anyone with eye concerns. This first-of-its-kind formula is clinically proven to correct the look of dark circles, discoloration, puffy eye bags, crepey skin, hooded eyelids, and fine lines and wrinkles — all in one powerful serum. Learn more about how EYE Serum can do here. [NOTE: Will link to EYE Serum blog] 

 

Best Exosome for the Face FAQ 

What do exosomes do for the face?

Exosomes act as the skin’s natural fuel to rewind visible signs of aging. By renewing the look of the skin, they reverse the look of damage. That means whether your skin is struggling with the look of fine lines, dark spots, redness, uneven tone, thinning skin, or all of the above, exosomes can help fix the visible issues that bother you most.  All that adds up to a healthier-, more youthful-looking complexion—uncovering your best skin yet and your truest beauty from within.

What is the best form of exosomes?

Platelet-derived exosomes are considered the most effective for facial skincare. They’re packed with phosphoproteins, peptides, and antioxidants that visibly refresh the skin and reverse visible signs of aging. Because they speak the language of your skin, they can help with multiple different skin concerns at once from the look of dark spots to wrinkles, rough texture to large pores, sagging skin to dullness, and more. All while being safe and effective for sensitive skin.

How many exosome treatments are needed for the face?

With consistent daily use, many people see visible improvements in about six weeks, with continued results over time.

Where can I buy exosome serums for face treatment online?

You can purchase dermatologist-recommended exosome serums directly from the

( plated )® Skin Science website, ensuring authentic, properly stored formulations.

What are the top-rated exosome products recommended by dermatologists?

( plated )® Skin Science is the #1 dermatologist recommended exosome skincare. INTENSE Serum, DAILY Serum, and EYE Serum are top-rated thanks to the power of platelet-derived exosomes and strong clinical validation.

How does exosome skincare compare with traditional skincare products? Traditional skincare targets one issue at a time and can lead to irritation from over-layering. Exosome skincare supports broad, visible renewal by working with your skin’s natural processes — delivering multiple benefits with one intelligent technology.

 

SOURCES 

Proffer, S. L., Paradise, C. R., DeGrazia, E., Halaas, Y., Durairaj, K. K., Somenek, M., Sivly, A., Boon, A. J., Behfar, A., & Wyles, S. P. (2022). Efficacy and Tolerability of Topical Platelet Exosomes for Skin Rejuvenation: Six-Week Results. Aesthetic surgery journal, 42(10), 1185–1193. 

Wyles, S. P., Yu, G. T., Gold, M., & Behfar, A. (2024). Topical Platelet Exosomes Reduce Senescence Signaling in Human Skin: An Exploratory Prospective Trial. Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 50(11S), S160–S165