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( plated ) DAILY Serum Refill cartridge
( plated ) Skin Science 30 mL DAILY Refill Serum bottle, refill cartridge, and packaging with text that states 'DAILY Serum Refills are exclusively available for our upgraded packaging.
Video showing the DAILY Serum bottle and product.
Hands holding a value-size bottle of ( plated ) DAILY Serum, labeled '2x larger than INTENSE Serum'.
Scientific rendering of an exosome featuring the text 'Powered by Renewosome™ technology. Our platelet-derived Renewosome™ exosomes are the ultimate powerhouse, working to renew the look of your skin.'
( plated ) Skin Science DAILY Serum Refill cartridge and packaging, 30 mL / 1 fl oz
4.7
Rated 4.7 out of 5 stars
232

DAILY Serum Refill

Renewing Support for Youthful, Radiant Skin

Sale price$244.00
30 mL Refill 30 mL Bottle

Visible transformation takes time. With each use, platelet-derived exosomes help support your skin’s natural renewal, driving results that continue to build long-term. Our refillable design keeps you consistent, with $14 savings built into every bottle.

Size: 30 mL / 1 fl oz

MUST have the full-size DAILY Serum for the refill to work properly.

Ingredients

Platelet-Derived Exosomes

Exosomes deliver signals that help skin renew and repair.

Glycerin

Gold standard humectant that locks in moisture to help balance and protect compromised skin.

Polyacrylate Crosspolymer-6

Helps nourish skin, while shielding the surface of the skin from environmental damage. (also known as - PAC6)

All Ingredients

water, glycerin, pentylene glycol, polyacrylate crosspolymer-6, Human Platelet Extract, caprylyl glycol, 1,2-hexanediol, arginine, hydrolyzed gelatin, silanetriol

Instructions

Apply 1–2 times daily on clean, dry skin before any other skincare. Wait 5 minutes before layering additional products. Results amplify over time with consistent use.

Awards

Oprah Daily Editor's Choice 2023
( plated ) DAILY Serum Refill cartridge
DAILY Serum Refill Sale price$244.00
Hand reaching towards a silver ( plated ) DAILY Serum skincare bottle

Renew. Refill. Repeat.

How to Refill

Step 1: Twist the bottom of the reusable pump to remove the empty cartridge.

Step 2: Unscrew the cap of the new refill cartridge, insert into the pump, and twist to secure.

Step 3: Close your empty cartridge and recycle. Enjoy your exosomes!
Silver ( plated ) DAILY Serum bottle next to droplets of serum

Patience Makes Perfect

Platelet-derived exosomes support your skin’s natural renewal process for results that build over time. In clinical studies, results continued to improve long-term, helping to:

  • Reveal brighter, more luminous skin 
  • Smooth the look of fine lines and wrinkles
  • Fight the look of redness and dark spots
  • Defends against future signs of aging

Exosome Science in Action

Visibly Transformative Results

Before-and-after comparison of a man's face showing visible skin barrier improvement over 12 weeks.
Before and after comparison of a person's face with visible skin texture changes over 12 weeks.
Before and after comparison of a person's face, showing visible improvement over 6 weeks.

Where Biotech Meets Beauty™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

EXPLORE THE SCIENCE
4.7
Rated 4.7 out of 5 stars
Based on 232 reviews
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232 reviews
  • Marcia C.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/14/26
    Awesomeness

    This product is a little pricey but worth it! I’ve been using it for 2 months and will definitely continue. I’m 72 years old and played is gradually erasing my crepy arms and legs. Thank you for this wonderful product

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  • Pamela A.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/14/26
    Love this product!

    I am 67 with aging skin that I refuse to abandon without giving it all I have. This product, as well as the intense serum, is exception and I use it daily. My skin loves it and I am often mistaken for being in my 50s. My perspective is the first thing anyone looks at is your face and skin reflects so much. Along with a healthy diet and hydration, skin science products are worth every penny. <3

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  • Mary L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/13/26
    Daily

    Love the daily and refill!

    Was this helpful?
  • Christy C.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/13/26
    Best Serum

    Recommended by my Dermatologist and my skin has never looked better.

    Was this helpful?
  • Renee L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/13/26
    Amazing results

    This product if effective and the results show. I saw my skin change with the fine lines and the discoloration! Highly recommend

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  • Susannah S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/12/26
    Great Products!

    Love these products!

    Was this helpful?
  • Rebecca N.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/12/26
    Really works!

    My dermatologist recommended Plated Daily serum as part of my skincare routine. The results have been fantastic. It’s kept my skin tone even and healthy looking and my dark spots have not returned. I’ve been using it daily for over a year and I consider it an essential part of my skins care.

    Was this helpful?
  • Valerie D.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/12/26
    Lovely texture

    Light, well absorbed and leaves a smooth finish before applying makeup. My skin is naturally oily so I’ve found that every other day is enough, otherwise, I tend to break out. It works so well though, that I’m not willing to give it up!

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  • Trisha S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/11/26
    Worth every penny

    I was hesitant to purchase this because of the cost, and I’m happily eating my words! I’ve always had good skin, but as I’ve aged I’ve been dealing with redness and discoloration. Within a month the changes were REMARKABLE. I’m not one to take “selfies” but I wish I had a good before/after. The comments I get from women much younger than me always make my day ;)

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  • Robert B.
    Verified Buyer
    Rated 3 out of 5 stars
    9/11/26
    Solid performing serum

    This serum works better for me than any I have tried so it has become a staple in my daily skincare routine. The reason for the lower rating is that the delivery system has failed a few times and have to use a cotton swab to get remaining product out of the bottle.

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DAILY Serum Refill

Frequently Asked Questions

What is ( plated ) DAILY Serum?

DAILY Serum is our deeply hydrating, platelet-derived exosome serum, known as the "glow" serum, powered by proprietary Renewosome® technology. This medical-grade formula infuses the skin with visible renewal for everyday radiance, applied once daily.

What does ( plated ) DAILY Serum do?

DAILY Serum deeply hydrates and infuses the skin with visible renewal to improve radiance. Clinically, it's been shown to reveal brighter skin, smooth the look of fine lines, and reduce the appearance of redness and dark spots, while helping defend against future signs of aging.

Who is ( plated ) DAILY Serum for?

DAILY Serum for anyone looking for daily anti-aging protection and a luminous glow. Its gentle, hydrating formula makes it an especially good fit for sensitive or barrier-compromised skin. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

When should I use ( plated ) DAILY Serum?

DAILY Serum can be used either in the morning or at night as the first step in your skincare routine.

How often should I apply ( plated ) DAILY Serum?

DAILY Serum is formulated for everyday use. Apply to clean, dry skin 1–2 times daily. Wait 5 minutes before layering any other skincare product.

Can I use ( plated ) DAILY Serum with other skincare products?

Yes! For best results, always apply ( plated ) exosome serums first to clean, product-free skin. And let it sit for 5 minutes before applying other products.

The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. After waiting 5 minutes, feel free to layer on any other products, such as retinol, retinoids, vitamin C, moisturizer, or sunscreen. Don't forget your SPF.

Is ( plated ) DAILY Serum suitable for all skin types?

Yes. DAILY Serum is formulated to be gentle and hydrating, making it appropriate for all skin types, including sensitive skin.

After a skin procedure such as laser, microneedling, or a chemical peel, and after using ( plated ) CALM Serum post-procedure, is ( plated ) DAILY Serum the best to transition to afterward?

You may choose to stick to CALM Serum or transition to DAILY Serum (renewing support for a youthful glow) or INTENSE Serum (maximum exosome concentration for mature or stressed skin). Your provider can help you select the best choice for your skin goals.