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( plated ) Skin Science INTENSE Serum bottle with 'Time' magazine's 'Best Inventions' award badge
Gold skincare bottle labeled ( plated ) INTENSE Serum on a gold background with white text describing how the product reduces the appearance fine lines and wrinkles, improves luminosity, and reduces the appearance of redness and discoloration.
Diagram of science-backed ingredients in ( plated )'s skincare with text describing the Renewosome® Technology, Hyaluronic Acid, and Antioxidants.
Before-and-after comparison of the eye area with text indicating improvement in the appearance of fine lines and wrinkles after 12 weeks of daily use.
Before-and-after comparison of a woman's face with text indicating an improvement in the appearance of luminosity after 6 weeks of daily use.
Scientific rendering of an exosome with text about Renewosome™ Technology.
Hand holding an INTENSE Serum bottle with application instructions on a beige background
Video of ( plated ) INTENSE Serum on display and being applied to a model's face and finger.
Video of the INTENSE Serum 15 mL bottle coming apart to reveal the refill cartridge on a white background.
( plated )® Skin Science INTENSE Serum bottle and packaging.
4.7
Rated 4.7 out of 5 stars
849

Our Most Advanced Exosome Serum

INTENSE Serum

Sale price$258.00
15 mL Bottle 15 mL Refill

Target multiple visible signs of aging with our most concentrated exosome serum. Powered by 1+ trillion platelet-derived exosomes, INTENSE Serum helps visibly improve skin quality with results that continue to build over time.

Clinically proven to:

  • Deliver 2x younger-looking skin
  • Reduce the appearance of fine lines and wrinkles
  • Fight the look of dark spots and uneven tone
  • Boost luminosity and promote a radiant glow

Size

15mL / 0.5 fl oz

Ingredients

Platelet-Derived Exosomes

Nanosized vesicles that unlock the skin’s innate ability to renew, visibly rewinding the look of damaged, aging skin.

Hyaluronic Acid

Low-weight hyaluronic acid supports renewing potential of exosomes, while increasing skin hydration.

Innovative Antioxidant Blend

Reduces free radical damage to help skin maintain a healthy, youthful appearance.

All Ingredients

water, glycerin, pentylene glycol, panthenol, human platelet extract, polyacrylate crosspolymer-6, hyaluronic acid, caprylyl glycol, 1,2-hexanediol, hydrolyzed gelatin, arginine, silanetriol

Instructions

Apply 1–2 times daily on clean, dry skin before any other skincare. Wait 5 minutes before layering additional products. Results amplify over time with consistent use.

Awards

TIME Best Inventions 2024

Oprah Daily Editor's Choice 2024

Oprah Daily Editor's Choice 2023

NewBeauty Award Winner 2025

NewBeauty Award Winner 2024

GQ Grooming Award 2025

Cosmopolitan Holy Grail Beauty Award 2025

Marie Claire Hair & Skin Award (Best Serum for Mature Skin) 2025
( plated ) Skin Science INTENSE Serum bottle with 'Time' magazine's 'Best Inventions' award badge
INTENSE Serum Sale price$258.00

Intensively & Rapidly Combats

Multiple Signs of Aging

Our highest concentration of exosomes to deliver science-backed, anti-aging results:

  • 2x younger- and brighter-looking skin
  • 94% experienced healthier-looking skin
  • 26% reduction in the appearance of wrinkles
  • 25% reduction in the appearance of dark spots
  • 1.25x firmer-looking skin
Hand holding a gold ( plated ) INTENSE Serum bottle, applying product to another hand.

Best Suited For

  • Stressed or aging skin
  • Safe and effective for all skin types, including sensitive skin
  • Non-comedogenic and will not clog pores
  • Enhances glow & luminosity in as little as 4 weeks
  • Benefits amplify with continued use
  • Pairs well with EYE Serum

Exosomes in Action

Visibly Transformative Results

Calmer-Looking, More Even Tone

Before

Before

At 12 Weeks

At 12 Weeks

Smoother-Looking Texture & Fine Lines

Before

Before

At 12 Weeks

At 12 Weeks

Reduced Appearance of Dark Spots

Before

Before

At 12 Weeks

At 12 Weeks

Smoother-, More Even-Looking Hands

Before

Before

At 12 Weeks

At 12 Weeks

Where Biotech Meets Beauty™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

EXPLORE THE SCIENCE

See What They're saying

Customer Reviews

4.7
Rated 4.7 out of 5 stars
Based on 849 reviews
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849 reviews
  • Nadia P.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/19/26
    Great!

    Love this product as I approach 40

    Was this helpful?
  • Leah L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/19/26
    The one must have in my routine

    I have a very simple skincare routine, but this is the one investment that I do not regret and is a must. I’ve noticed that my skin has less redness, has improved the texture and fine lines.

    Was this helpful?
  • Laurie K.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    9/19/26
    only time will tell!

    I like the product from a day to day perspective. It goes on easily and I haven't had any irritation. I haven't really noticed any difference in my skin, but since the goal is to reduce the signs of aging, I guess only time will tell! I still plan on continuing it.

    Was this helpful?
  • Michelle S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/19/26
    Best product I’ve used

    From skin medica to skin ceuticals, hydrinity, and all other medical grade products this by far beats them in with results overall for sagging wrinkles laxity firming and removes all dark spots! It is worth every penny and make sure to subscribe so you see resurfacing results overtime.

    Was this helpful?
  • Stacey R.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    9/19/26
    Love it!

    My skin feels younger and fresh!

    Was this helpful?
  • Jan S.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/19/26
    What a difference!

    I love the intense plated serum and am very pleased they make a refill option. My skin has never looked better and I have been receiving lots of compliments on it! I can’t think of a better recommendation than that to continue using plated products.

    Was this helpful?
  • Cara B.
    Verified Buyer
    I recommend this product
    Rated 4 out of 5 stars
    9/19/26
    Only used a month so far

    I haven’t been using this long enough to see a difference. Honestly I Should’ve taken a before picture. My skim already looked good. I am only using once a day

    Was this helpful?
  • charlene s. d.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/19/26
    Noticeable results over 2 1/2 months

    I began using intense serum in early July on my perioral region and neck, and have noted gradual clear decrease in wrinkle depth and length of a deep persistent wrinkle in the right perioral region. I’ve also noted decrease in mild upper and lower lip wrinkles. I’d hoped for improvement in crepey texture of mid neck but so far no noticeable improvement in that area.

    I am a physician and will be recommending this serum to my patients with concerns of deep persistant facial wrinkling.

    Was this helpful?
  • Denise m.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/18/26
    Little goes along way

    Helps calm and tighten my skin . Makes makeup application easy. Gives a all day long glow🤗

    Was this helpful?
  • Theresia V.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/18/26
    Love this Serum

    I was given a bottle to try by a sales rep almost 2 years ago & haven’t stopped since. I’m almost 58 years old & get compliments on my skin always.

    Was this helpful?
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INTENSE Serum

Frequently Asked Questions

What is ( plated ) INTENSE Serum?

INTENSE Serum is our most concentrated anti-aging exosome serum, powered by proprietary Renewosome® technology. It's a medical-grade formula designed for the most challenging skin concerns: fine lines, wrinkles, redness, brown spots, and uneven tone and texture. Apply once daily.

What does ( plated ) INTENSE Serum do?

INTENSE Serum helps improve the appearance of the most challenging signs of aging: fine lines, wrinkles, redness, brown spots, and uneven tone and texture.

Clinically, it's been shown to deliver 2x younger-looking skin, reduce the appearance of wrinkles and dark spots, and boost luminosity and glow. Most people see visible results within 6 weeks, with a transformation that builds over time.

Who is ( plated ) INTENSE Serum for?

INTENSE Serum is for anyone looking to target more advanced or stubborn signs of aging with our most concentrated formula. It's suitable for all skin types and is an especially strong fit when fine lines, wrinkles, brown spots, or uneven tone and texture are your top concerns. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

How often should I apply ( plated ) INTENSE Serum?

Apply INTENSE Serum 1 to 2 times per day on a dry face right after cleansing. Wait 5 minutes to allow the platelet-derived exosomes to get to work before layering any other products. With millions of exosomes per pump, one pump per application is all you need.

Do I use ( plated ) INTENSE and DAILY Serum at the same time?

Depending on your individual skin goals and your aesthetic provider's guidance, INTENSE Serum and DAILY Serum can be used as part of the same anti-aging regimen. Start your morning with DAILY Serum, drenching skin in hydration while supporting your barrier and bringing out a healthy, lit-from-within glow. At night, switch to INTENSE Serum, working in sync with your skin's natural renewal cycle to visibly smooth, refine, and restore while you sleep.

Can you use the ( plated ) INTENSE Serum with other products like retinol or vitamin C?

Yes! In fact, according to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol.

For best results, always apply ( plated ) serums first to clean, product-free skin. And let it sit for 5 minutes before applying other products. The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once you've waited, feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.

Does ( plated ) INTENSE Serum cause sun sensitivity?

No. Our INTENSE Serum will not cause sun sensitivity. You can apply it in the morning or at night as you wish. In fact, the platelet-derived exosomes that power Renewosome® technology have been shown to help deliver advanced environmental protection against oxidative damage from UVA/UVB rays, pollution, and more. Of course, we still recommend you use your favorite daily SPF.

After a skin procedure such as laser treatment, microneedling, or chemical peel, is it best to transition to ( plated ) INTENSE Serum after using ( plated ) CALM Serum?

You may choose to stick to CALM Serum or transition to INTENSE Serum (maximum exosome concentration for mature or stressed skin) or DAILY Serum (renewing support for a youthful glow). Your provider can help you select the best choice for your skin goals.

What makes ( plated ) INTENSE Serum worth the investment?

( plated ) Skin Science is the #1 dermatologist-recommended exosome brand for a reason: the science is backed by 10+ gold-standard clinical studies that show one thing: platelet-derived exosomes lead to visible transformation. As our most advanced exosome serum, INTENSE Serum delivers the most cutting-edge exosome science and technology to your skincare routine.

Developed by Mayo Clinic physician-scientists over 20+ years, ( plated ) serums represent a true breakthrough for aging skin. They harness the power of platelet-derived exosomes and their remarkable cargo to visibly renew the skin while remaining soothing and gentle. So many serums are only as good as the next cleanse.

Don't forget, a little serum (just one pump) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use. An investment, for sure. Clinical studies show a compounding effect; the longer you use INTENSE Serum, the more your results build. Think of it like a long-term investment for your skin, where every application adds up over time.

An investment for sure, but worth it? Definitely! You'll see these results for years to come.