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4.7
Rated 4.7 out of 5 stars
4.7 out of 5 Stars (1,036 Reviews)

Our Most Advanced Exosome Serum

INTENSE Serum

Sale price $258.00

Target multiple visible signs of aging with our most concentrated exosome serum. Powered by 1+ trillion platelet-derived exosomes, INTENSE Serum helps visibly improve skin quality with results that continue to build over time.

Clinically proven to:

  • Deliver 2x younger-looking skin
  • Reduce the appearance of fine lines and wrinkles
  • Fight the look of dark spots and uneven tone
  • Boost luminosity and promote a radiant glow

Size

15mL / 0.5 fl oz

Ingredients

Platelet-Derived Exosomes

Nanosized vesicles that unlock the skin’s innate ability to renew, visibly rewinding the look of damaged, aging skin.

Hyaluronic Acid

Low-weight hyaluronic acid supports renewing potential of exosomes, while increasing skin hydration.

Innovative Antioxidant Blend

Reduces free radical damage to help skin maintain a healthy, youthful appearance.

All Ingredients

water, glycerin, pentylene glycol, panthenol, human platelet extract, polyacrylate crosspolymer-6, hyaluronic acid, caprylyl glycol, 1,2-hexanediol, hydrolyzed gelatin, arginine, silanetriol

Instructions

Once or twice daily, begin your skincare routine with a gentle cleanser. Then, if desired, sweep a ( plated ) pad across your face and neck. Do not rinse.

Follow immediately with your ( plated ) serum. Allow 5 minutes before layering other products. With consistent use, results amplify over time.

Awards

TIME Best Inventions 2024

Skin Anarchy Top Picks Beauty Award, 2026

Oprah Daily Midlife Beauty O-Wards, 2026

Oprah Daily Editor's Choice 2024

Oprah Daily Editor's Choice 2023

NewBeauty Award Winner 2025

NewBeauty Award Winner 2024

GQ Grooming Award 2025

Cosmopolitan Holy Grail Beauty Award 2025

Marie Claire Hair & Skin Award (Best Serum for Mature Skin) 2025

Who What Wear 100 Beauty Awards - Best Multi-Tasking Serum

( plated ) Skin Science INTENSE Serum  bottle with 'Time' magazine's 'Best Inventions' award badge
INTENSE Serum Sale price $258.00

INTENSIVELY & RAPIDLY COMBATS

Multiple Signs of Aging

Our highest concentration of exosomes to deliver science-backed, anti-aging results:

  • 2x younger- and brighter-looking skin
  • 94% experienced healthier-looking skin
  • 26% reduction in the appearance of wrinkles
  • 25% reduction in the appearance of dark spots
  • 1.25x firmer-looking skin
Hand holding a gold ( plated ) INTENSE Serum bottle, applying product to another hand.

Best Suited For

  • Stressed or aging skin
  • Safe and effective for all skin types, including sensitive skin
  • Non-comedogenic and will not clog pores
  • Enhances glow & luminosity in as little as 4 weeks
  • Benefits amplify with continued use
  • Pairs well with EYE Serum

EXOSOMES IN ACTION

Visibly Transformative Results

Calmer-Looking, More Even Tone

Before: Three-quarter view of a woman's face with visible redness across the nose and cheeks, scattered dark spots, and uneven skin tone.

Before

After: Three-quarter view of the same woman's face with visible redness, freckles, and a more even-looking complexion across the cheeks.

At 12 Weeks

Smoother-Looking Texture & Fine Lines

Before: Close-up of a woman's closed eye showing fine lines, crow's feet, and visible skin texture around the outer corner.

Before

After: Close-up of the same closed eye showing the reduced appearance of fine lines and smoother-looking skin around the outer corner.

At 12 Weeks

Reduced Appearance of Dark Spots

Before: Close-up of the forehead showing scattered brown spots, freckles, and uneven-looking pigmentation.

Before

After: Close-up of the same forehead showing visibly fewer freckles, brown spots, and a more even-looking skin tone.

At 12 Weeks

Smoother-, More Even-Looking Hands

Before: Close-up of the back of a hand showing brown spots, prominent veins, fine lines, and uneven skin texture.

Before

After: Close-up of the same hand showing a visible reduction in the appearance of brown spots and smoother-looking skin.

At 12 Weeks

WHERE BIOTECH MEETS BEAUTY™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

SEE WHAT THEY'RE SAYING

Customer Reviews

4.7
Rated 4.7 out of 5 stars
Based on 1,036 reviews
Slide 1 selected
1,036 reviews
  • Adie G.
    Verified Buyer
    I recommend this product
    Age 60–69
    Rated 5 out of 5 stars
    11/2/26
    Recommend

    Great cream. It leaves your skin soft. It has lighten my pigmentation & it glows.

  • Marguerite K.
    Verified Reviewer
    I recommend this product
    Age 60–69
    Rated 5 out of 5 stars
    11/2/26
    Lifetime of Skincare but This is the Best!

    Spent a career working for a top Japanese skincare company so I’ve taken excellent care of my skin with daily massage, extensive skincare and sunscreen. So I do look young for my 68 years but this product is a game-changer! I was shocked at the firming and smoothing effect. I still need other moisturizers for hydration but I’ve given up the other serums and retinol and my skin and pocketbook are thankful. Love this.

  • kristin s.
    Verified Buyer
    I recommend this product
    Age 60–69
    Rated 5 out of 5 stars
    11/2/26
    Love it

    Nothing like this serum! Love it! Have used 2 bottles and getting ready to order another refill!

  • Natasha H.
    Verified Buyer
    I recommend this product
    Age 30–39
    Rated 5 out of 5 stars
    11/2/26
    My holy grail

    Holy moly I love this product so much. Though I hate to admit, as time continues I continue to get older, but this product has become such a staple in my skincare routine to age gracefully. This product is so lightweight but packs quite the punch. So glad I have it, and I recommend it to anyone wanting to amp up their skincare.

  • Natasha H.
    Verified Buyer
    I recommend this product
    Age 30–39
    Rated 5 out of 5 stars
    11/2/26
    Amazing

    Obsessed with this product in every way I love that (plated) made it so user-friendly to refill their fantastic product. Thank you!

  • Linda B.
    Verified Buyer
    I recommend this product
    Age 70+
    Rated 5 out of 5 stars
    11/2/26
    Great stuff

    I just had a face lift and CO2 laser and I have the plate of serum and eye serum and their stuff is just magical on my skin. It actually soothedthe itching.

  • paula p.
    Verified Buyer
    I recommend this product
    Age 70+
    Rated 4 out of 5 stars
    11/1/26
    Intense serum

    I use this twice a day. I am 72. I believe a see a difference in wrinkles around my mouth

  • Lynn C.
    Verified Buyer
    I recommend this product
    Age 60–69
    Rated 5 out of 5 stars
    11/1/26
    Love it!!

    Redness is reduced so much.

  • Judith D.
    Verified Buyer
    I recommend this product
    Age 70+
    Rated 5 out of 5 stars
    10/31/26
    Refill a genius

    Terrific product. it really works and being able to choose a refill saves money! Genius!

  • Carolyn B.
    Verified Buyer
    I recommend this product
    Age 70+
    Rated 5 out of 5 stars
    10/31/26
    Intense Serum

    I only wish I had taken a Before photo because I would be even more amazed with my results after having used Intense Serum for six months now. I had some dark spots that have completely faded, others are much smaller now and with continued use will also disappear. Texture of my skin is much smoother and I am so impressed. Love seeing the improvements. My dream, a whole body product that I can afford! Thank you, Plated skin science!

INTENSE Serum

Frequently Asked Questions

What is ( plated ) INTENSE Serum?

INTENSE Serum is our most concentrated anti-aging exosome serum, powered by proprietary Renewosome® technology. It's a medical-grade formula designed for the most challenging skin concerns: fine lines, wrinkles, redness, brown spots, and uneven tone and texture. Apply once daily.

What does ( plated ) INTENSE Serum do?

INTENSE Serum helps improve the appearance of the most challenging signs of aging: fine lines, wrinkles, redness, brown spots, and uneven tone and texture.

Clinically, it's been shown to deliver 2x younger-looking skin, reduce the appearance of wrinkles and dark spots, and boost luminosity and glow. Most people see visible results within 6 weeks, with a transformation that builds over time.

Who is ( plated ) INTENSE Serum for?

INTENSE Serum is for anyone looking to target more advanced or stubborn signs of aging with our most concentrated formula. It's suitable for all skin types and is an especially strong fit when fine lines, wrinkles, brown spots, or uneven tone and texture are your top concerns. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

How often should I apply ( plated ) INTENSE Serum?

Once or twice daily, begin your skincare routine with a gentle cleanser. Then, if desired, sweep a ( plated ) pad across your face and neck. Do not rinse. Follow immediately with your ( plated ) serum. Allow 5 minutes before layering other products. With consistent use, results amplify over time. With millions of exosomes per pump, one pump per application is all you need.

Do I use ( plated ) INTENSE and DAILY Serum at the same time?

Depending on your individual skin goals and your aesthetic provider's guidance, INTENSE Serum and DAILY Serum can be used as part of the same anti-aging regimen. Start your morning with DAILY Serum, drenching skin in hydration while supporting your barrier and bringing out a healthy, lit-from-within glow. At night, switch to INTENSE Serum, working in sync with your skin's natural renewal cycle to visibly smooth, refine, and restore while you sleep.

Can you use the ( plated ) INTENSE Serum with other products like retinol or vitamin C?

Yes! In fact, according to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol.

For best results, always apply ( plated ) serums first to clean, product-free skin. And let it sit for 5 minutes before applying other products. The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once you've waited, feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.

Does ( plated ) INTENSE Serum cause sun sensitivity?

No. Our INTENSE Serum will not cause sun sensitivity. You can apply it in the morning or at night as you wish. In fact, the platelet-derived exosomes that power Renewosome® technology have been shown to help deliver advanced environmental protection against oxidative damage from UVA/UVB rays, pollution, and more. Of course, we still recommend you use your favorite daily SPF.

After a skin procedure such as laser treatment, microneedling, or chemical peel, is it best to transition to ( plated ) INTENSE Serum after using ( plated ) CALM Serum?

You may choose to stick to CALM Serum or transition to INTENSE Serum (maximum exosome concentration for mature or stressed skin) or DAILY Serum (renewing support for a youthful glow). Your provider can help you select the best choice for your skin goals.

What makes ( plated ) INTENSE Serum worth the investment?

( plated ) Skin Science is the #1 dermatologist-recommended exosome brand for a reason: the science is backed by 10+ gold-standard clinical studies that show one thing: platelet-derived exosomes lead to visible transformation. As our most advanced exosome serum, INTENSE Serum delivers the most cutting-edge exosome science and technology to your skincare routine.

Developed by Mayo Clinic physician-scientists over 20+ years, ( plated ) serums represent a true breakthrough for aging skin. They harness the power of platelet-derived exosomes and their remarkable cargo to visibly renew the skin while remaining soothing and gentle. So many serums are only as good as the next cleanse.

Don't forget, a little serum (just one pump) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use. An investment, for sure. Clinical studies show a compounding effect; the longer you use INTENSE Serum, the more your results build. Think of it like a long-term investment for your skin, where every application adds up over time.

An investment for sure, but worth it? Definitely! You'll see these results for years to come.