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( plated ) Skin Science INTENSE Serum bottle with 'Time' magazine's 'Best Inventions' award badge
Gold skincare bottle labeled ( plated ) INTENSE Serum on a gold background with white text describing how the product reduces the appearance fine lines and wrinkles, improves luminosity, and reduces the appearance of redness and discoloration.
Diagram of science-backed ingredients in ( plated )'s skincare with text describing the Renewosome® Technology, Hyaluronic Acid, and Antioxidants.
Before-and-after comparison of the eye area with text indicating improvement in the appearance of fine lines and wrinkles after 12 weeks of daily use.
Before-and-after comparison of a woman's face with text indicating an improvement in the appearance of luminosity after 6 weeks of daily use.
Scientific rendering of an exosome with text about Renewosome™ Technology.
Hand holding an INTENSE Serum bottle with application instructions on a beige background
Video of ( plated ) INTENSE Serum on display and being applied to a model's face and finger.
Video of the INTENSE Serum 15 mL bottle coming apart to reveal the refill cartridge on a white background.
( plated )® Skin Science INTENSE Serum bottle and packaging.
4.7
Rated 4.7 out of 5 stars
879

Our Most Advanced Exosome Serum

INTENSE Serum

Sale price$258.00
15 mL Bottle 15 mL Refill

Target multiple visible signs of aging with our most concentrated exosome serum. Powered by 1+ trillion platelet-derived exosomes, INTENSE Serum helps visibly improve skin quality with results that continue to build over time.

Clinically proven to:

  • Deliver 2x younger-looking skin
  • Reduce the appearance of fine lines and wrinkles
  • Fight the look of dark spots and uneven tone
  • Boost luminosity and promote a radiant glow

Size

15mL / 0.5 fl oz

Ingredients

Platelet-Derived Exosomes

Nanosized vesicles that unlock the skin’s innate ability to renew, visibly rewinding the look of damaged, aging skin.

Hyaluronic Acid

Low-weight hyaluronic acid supports renewing potential of exosomes, while increasing skin hydration.

Innovative Antioxidant Blend

Reduces free radical damage to help skin maintain a healthy, youthful appearance.

All Ingredients

water, glycerin, pentylene glycol, panthenol, human platelet extract, polyacrylate crosspolymer-6, hyaluronic acid, caprylyl glycol, 1,2-hexanediol, hydrolyzed gelatin, arginine, silanetriol

Instructions

Apply 1–2 times daily on clean, dry skin before any other skincare. Wait 5 minutes before layering additional products. Results amplify over time with consistent use.

Awards

TIME Best Inventions 2024

Oprah Daily Editor's Choice 2024

Oprah Daily Editor's Choice 2023

NewBeauty Award Winner 2025

NewBeauty Award Winner 2024

GQ Grooming Award 2025

Cosmopolitan Holy Grail Beauty Award 2025

Marie Claire Hair & Skin Award (Best Serum for Mature Skin) 2025
( plated ) Skin Science INTENSE Serum bottle with 'Time' magazine's 'Best Inventions' award badge
INTENSE Serum Sale price$258.00

Intensively & Rapidly Combats

Multiple Signs of Aging

Our highest concentration of exosomes to deliver science-backed, anti-aging results:

  • 2x younger- and brighter-looking skin
  • 94% experienced healthier-looking skin
  • 26% reduction in the appearance of wrinkles
  • 25% reduction in the appearance of dark spots
  • 1.25x firmer-looking skin
Hand holding a gold ( plated ) INTENSE Serum bottle, applying product to another hand.

Best Suited For

  • Stressed or aging skin
  • Safe and effective for all skin types, including sensitive skin
  • Non-comedogenic and will not clog pores
  • Enhances glow & luminosity in as little as 4 weeks
  • Benefits amplify with continued use
  • Pairs well with EYE Serum

Exosomes in Action

Visibly Transformative Results

Calmer-Looking, More Even Tone

Before

Before

At 12 Weeks

At 12 Weeks

Smoother-Looking Texture & Fine Lines

Before

Before

At 12 Weeks

At 12 Weeks

Reduced Appearance of Dark Spots

Before

Before

At 12 Weeks

At 12 Weeks

Smoother-, More Even-Looking Hands

Before

Before

At 12 Weeks

At 12 Weeks

Where Biotech Meets Beauty™

Discover the Power of Exosomes

Meet the most innovative topical ingredient in decades. Platelet-derived exosomes don’t mask the signs of aging; they reprogram the appearance of skin and hair. 

EXPLORE THE SCIENCE

See What They're saying

Customer Reviews

4.7
Rated 4.7 out of 5 stars
Based on 879 reviews
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879 reviews
  • Heysel Z.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/26/26
    Love it!

    I’m on my 3rd refill and it’s made a huge improvement on the redness and dark spots of my skin. I use it 2x per day. I started to see a difference on my 2nd refill, but I was very consistent. Will definitely continue to use it.

    Was this helpful?
  • Kate T.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/25/26
    My Skin Has Never Looked Better!!

    I genuinely cannot say enough good things about INTENSE Serum. This has become one of those products I never want to be without. My skin looks noticeably healthier, smoother, more hydrated and just overall more youthful since adding it to my routine. The biggest difference for me is the overall quality of my skin.. it looks more plump, refreshed and radiant and I’ve noticed an improvement in the appearance of fine lines and texture as well. I’ve tried a LOT of highend skincare and this is one of the few products I feel is truly worth the investment. It layers beautifully with the rest of my routine, never feels heavy or irritating.. and I have very sensitive skin as is. It gives my skin that healthy, expensive-looking glow. Absolutely a 5-star product and a permanent staple in my routine.

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  • Liza C.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/25/26
    It’s Working

    Heard about this product and then searched for reviews and credible support for it.

    It’s expensive, but I ordered it. Used my first bottle sparingly. Next I ordered a refill and committed to 2x daily. I started to see results. My skin seemed brighter, something noticeable each time I looked in a mirror. I’ve ordered my next refill. I think I’ll be trying the body product next.

    Was this helpful?
  • Jennifer W.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/25/26
    Intense serum

    Wonderful product! Results are amazing,

    Was this helpful?
  • Danielle P.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/24/26
    5 weeks

    After 5 weeks I cannot believe my reduction in redness! My rosacea LOVES THIS STUFF!

    Was this helpful?
  • COURTNEY G.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/24/26
    Plated saves lives

    I tried plated for my very first time a few years ago and I can’t live without it (trust me… I’ve tried). The way it makes me feel is amazing, and it does wonders for my skin.

    I also talk about plated with everyone I ever talk about skin with.

    Live, laugh, plated 🩷

    Was this helpful?
  • Terri F.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/24/26
    Happy to find a refill

    My Dr. recommended this..I bought the original one from him and did not kneow there was a refill

    Was this helpful?
  • Phyllis P.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/24/26
    One of my favs

    I have been using this product for almost a year. I have noticed a significant improvement in fine lines as well as the neck /decollate. My dermatologist recommended it following CO2 laser treatment, and I’ve kept this product in my daily regiment..

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  • Susan M.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/23/26
    Incredible Product

    My dermatologist's office recommended Plated Intense Serum to me. I started using it every day since January 2006. 8 months later, My skin has never looked better. I have never received so many compliments on how great my skin looks.

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  • Connie L.
    Verified Buyer
    I recommend this product
    Rated 5 out of 5 stars
    9/23/26
    Great product!

    I love this product. I’ve seen improvement in my overall texture and with fine lines.

    Was this helpful?
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INTENSE Serum

Frequently Asked Questions

What is ( plated ) INTENSE Serum?

INTENSE Serum is our most concentrated anti-aging exosome serum, powered by proprietary Renewosome® technology. It's a medical-grade formula designed for the most challenging skin concerns: fine lines, wrinkles, redness, brown spots, and uneven tone and texture. Apply once daily.

What does ( plated ) INTENSE Serum do?

INTENSE Serum helps improve the appearance of the most challenging signs of aging: fine lines, wrinkles, redness, brown spots, and uneven tone and texture.

Clinically, it's been shown to deliver 2x younger-looking skin, reduce the appearance of wrinkles and dark spots, and boost luminosity and glow. Most people see visible results within 6 weeks, with a transformation that builds over time.

Who is ( plated ) INTENSE Serum for?

INTENSE Serum is for anyone looking to target more advanced or stubborn signs of aging with our most concentrated formula. It's suitable for all skin types and is an especially strong fit when fine lines, wrinkles, brown spots, or uneven tone and texture are your top concerns. As with all ( plated ) serums, your provider can help confirm it's the right match for your skin.

How often should I apply ( plated ) INTENSE Serum?

Apply INTENSE Serum 1 to 2 times per day on a dry face right after cleansing. Wait 5 minutes to allow the platelet-derived exosomes to get to work before layering any other products. With millions of exosomes per pump, one pump per application is all you need.

Do I use ( plated ) INTENSE and DAILY Serum at the same time?

Depending on your individual skin goals and your aesthetic provider's guidance, INTENSE Serum and DAILY Serum can be used as part of the same anti-aging regimen. Start your morning with DAILY Serum, drenching skin in hydration while supporting your barrier and bringing out a healthy, lit-from-within glow. At night, switch to INTENSE Serum, working in sync with your skin's natural renewal cycle to visibly smooth, refine, and restore while you sleep.

Can you use the ( plated ) INTENSE Serum with other products like retinol or vitamin C?

Yes! In fact, according to a top dermatologist-researcher, ( plated ) may increase the efficiency of your other favorite skincare ingredients like vitamin C and retinol.

For best results, always apply ( plated ) serums first to clean, product-free skin. And let it sit for 5 minutes before applying other products. The platelet-derived exosomes in our Renewosome® technology work most effectively when they have direct access to your skin. Once you've waited, feel free to layer on any other products, such as ( plated ) EYE Serum, retinol, retinoid, vitamin C, moisturizer, sunscreen, etc.

Does ( plated ) INTENSE Serum cause sun sensitivity?

No. Our INTENSE Serum will not cause sun sensitivity. You can apply it in the morning or at night as you wish. In fact, the platelet-derived exosomes that power Renewosome® technology have been shown to help deliver advanced environmental protection against oxidative damage from UVA/UVB rays, pollution, and more. Of course, we still recommend you use your favorite daily SPF.

After a skin procedure such as laser treatment, microneedling, or chemical peel, is it best to transition to ( plated ) INTENSE Serum after using ( plated ) CALM Serum?

You may choose to stick to CALM Serum or transition to INTENSE Serum (maximum exosome concentration for mature or stressed skin) or DAILY Serum (renewing support for a youthful glow). Your provider can help you select the best choice for your skin goals.

What makes ( plated ) INTENSE Serum worth the investment?

( plated ) Skin Science is the #1 dermatologist-recommended exosome brand for a reason: the science is backed by 10+ gold-standard clinical studies that show one thing: platelet-derived exosomes lead to visible transformation. As our most advanced exosome serum, INTENSE Serum delivers the most cutting-edge exosome science and technology to your skincare routine.

Developed by Mayo Clinic physician-scientists over 20+ years, ( plated ) serums represent a true breakthrough for aging skin. They harness the power of platelet-derived exosomes and their remarkable cargo to visibly renew the skin while remaining soothing and gentle. So many serums are only as good as the next cleanse.

Don't forget, a little serum (just one pump) goes a long way. With millions of exosomes per pump, one pump per application is all you need. One bottle of INTENSE Serum contains approximately 64 pumps. That's over two months of use. An investment, for sure. Clinical studies show a compounding effect; the longer you use INTENSE Serum, the more your results build. Think of it like a long-term investment for your skin, where every application adds up over time.

An investment for sure, but worth it? Definitely! You'll see these results for years to come.